Updated:May, 2026

10 Best Natural Supplements For Depression of 2026

Best Choice

9.9

Outstanding

Happy Healthy Hippie

Joy-Filled Mood Support Supplement - 7 Herb Complex + St. Johns Wort | Stress Relief – Helps Calm The Mind & Body | 100% Plant-Based Happy Pills, Ashwagandha, Rhodiola Rosea | Adaptogens, 60 Ct

Why We Love It

[Joy-Filled: Calm A Worried Mind] Feel more in control of your life & don't let worries and tension get in the way. Our happy pills support stress relief and promotes an overall calming effect for the mind and body. One month supply.
[Mood Booster for Women & Men] Our ayurveda products can be the mood enhancer you're looking for. Our adaptogens formula is great for women and men looking for relaxation support and an effective stress relief supplement.
[7 Natural Herbs] Formulated with 7 healing herbs, our powerful mood support pills are designed to help with stress. Made with Ginkgo Biloba, Rhodiola Rosea, Ashwagandha Root Powder, Lemon Balm, support your mood w/ St. John's Wort & Eleuthero Root*
[Find Your Inner Joy] Our powerful brain and energy supplements helps increase key "feel-good" activities in your head, which are crucial components to maintaining a positive mood and avoiding unnecessary stress.
[100% Plant-Based] Our capsules are non-GMO, vegan. The herbs are grown naturally on farms around the world so that they can be brought straight from nature's garden into your home! Try our ashwagandha pills today and enjoy a natural way to find zen.

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Why We Love It

[Joy-Filled: Calm A Worried Mind] Feel more in control of your life & don't let worries and tension get in the way. Our happy pills support stress relief and promotes an overall calming effect for the mind and body. One month supply.
[Mood Booster for Women & Men] Our ayurveda products can be the mood enhancer you're looking for. Our adaptogens formula is great for women and men looking for relaxation support and an effective stress relief supplement.
[7 Natural Herbs] Formulated with 7 healing herbs, our powerful mood support pills are designed to help with stress. Made with Ginkgo Biloba, Rhodiola Rosea, Ashwagandha Root Powder, Lemon Balm, support your mood w/ St. John's Wort & Eleuthero Root*
[Find Your Inner Joy] Our powerful brain and energy supplements helps increase key "feel-good" activities in your head, which are crucial components to maintaining a positive mood and avoiding unnecessary stress.
[100% Plant-Based] Our capsules are non-GMO, vegan. The herbs are grown naturally on farms around the world so that they can be brought straight from nature's garden into your home! Try our ashwagandha pills today and enjoy a natural way to find zen.

How We Find the Top Picks

We use smart data tools to review thousands of products and stores, analyzing ratings, reviews, and popularity trends to highlight what truly matters to shoppers like you.

Our experts then refine the results, blending AI insights with real user experiences to deliver accurate, up-to-date rankings that help you choose with confidence.

9.5

Excellent

Zenium

Zenium Stress Relief Supplement Supports Mood & Mental Focus - Feel Calm and Relaxed - Eases Tension & Nervousness - Ashwagandha, Magnesium & L-Theanine - Great for Gift Items - 60 Capsules

Main Highlights

MADE IN THE USA - To ensure the highest quality, all Zenium products are tested, manufactured, and bottled in a 3rd-party tested facility in the United States for superior quality and consistency. All facilities are GMP-certified and follow strict quality specifications to ensure that each batch meets manufacturing requirements.
30-DAY SATISFACTION GUARANTEE - If you are on the fence about trying Zenium, dont be. We want you to be confident. If you do not feel like Zenium works for you please reach out to us directly, and we will issue a full refund. No questions asked.

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Main Highlights

MADE IN THE USA - To ensure the highest quality, all Zenium products are tested, manufactured, and bottled in a 3rd-party tested facility in the United States for superior quality and consistency. All facilities are GMP-certified and follow strict quality specifications to ensure that each batch meets manufacturing requirements.
30-DAY SATISFACTION GUARANTEE - If you are on the fence about trying Zenium, dont be. We want you to be confident. If you do not feel like Zenium works for you please reach out to us directly, and we will issue a full refund. No questions asked.

9.5

Excellent

Futurebiotics

Futurebiotics Chill Pill + Ashwagandha, Rhodiola, St. John’s Wort, & L-Theanine - Non-GMO, 120 Vegetarian Tablets

Main Highlights

Advanced Calming Formula*: Futurebiotics Chill Pill + provides premium ingredients that work synergistically.* Our advanced calming formula provides Ashwagandha, Rhodiola Rosea, St. John's Wort, and L-Theanine for superior support.*
Superior Quality GMO-Free: Carefully manufactured at our cGMP Registered Facility that is located in New York. Each and every Futurebiotics product is put through a rigorous process to ensure purity, potency and quality. Futurebiotics Chill Pill + is in-house tested and free of GMOs, Gluten & Soy.
Vegan/Vegetarian Formula: Futurebiotics Chill Pill + is Vegan/Vegetarian friendly and contains no ingredients derived from animals.
High Quality Ingredients: We strive to only seek the purest and superior quality ingredients from around the world.

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Main Highlights

Advanced Calming Formula*: Futurebiotics Chill Pill + provides premium ingredients that work synergistically.* Our advanced calming formula provides Ashwagandha, Rhodiola Rosea, St. John's Wort, and L-Theanine for superior support.*
Superior Quality GMO-Free: Carefully manufactured at our cGMP Registered Facility that is located in New York. Each and every Futurebiotics product is put through a rigorous process to ensure purity, potency and quality. Futurebiotics Chill Pill + is in-house tested and free of GMOs, Gluten & Soy.
Vegan/Vegetarian Formula: Futurebiotics Chill Pill + is Vegan/Vegetarian friendly and contains no ingredients derived from animals.
High Quality Ingredients: We strive to only seek the purest and superior quality ingredients from around the world.

9.2

Excellent

Boiron

Boiron StressCalm Tablets for Relief of Stress, Anxiousness, Nervousness, Irritability, and Fatigue - 60 Count

Main Highlights

PLANT-POWERED, MULTI-SYMPTOM STRESS RELIEF: StressCalm On the Go is powered by plants to relieve occasional symptoms of everyday stress, including nervous tension, irritability, hypersensitivity, and fatigue.* Its sedative-free, so you can stay focused and relaxed without feeling drowsy.
MELTAWAY TABLETS - NO WATER NEEDED: These easy-to-take unflavored meltaway tablets dissolve in your mouth without the need for water. They can be taken on an empty stomach, making them ideal for home, work, or on the go. Recommended for adults and children ages 12 and older.
NON-DROWSY FORMULA: Stay calm with StressCalm's sedative-free formula. Enjoy the benefits of relief without the worry of drowsiness.
A BETTER WAY TO FEEL BETTER: StressCalm is a homeopathic stress relief medicine that has no known interactions with other medications, herbs, or supplements. Its also gluten-free with no artificial sweeteners, flavors, colors, or preservatives.
A TRUSTED BRAND: With more than 90 years of expertise, Boiron medicines are manufactured to meet the highest standards of cGMP and HPUS for purity and quality.

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Main Highlights

PLANT-POWERED, MULTI-SYMPTOM STRESS RELIEF: StressCalm On the Go is powered by plants to relieve occasional symptoms of everyday stress, including nervous tension, irritability, hypersensitivity, and fatigue.* Its sedative-free, so you can stay focused and relaxed without feeling drowsy.
MELTAWAY TABLETS - NO WATER NEEDED: These easy-to-take unflavored meltaway tablets dissolve in your mouth without the need for water. They can be taken on an empty stomach, making them ideal for home, work, or on the go. Recommended for adults and children ages 12 and older.
NON-DROWSY FORMULA: Stay calm with StressCalm's sedative-free formula. Enjoy the benefits of relief without the worry of drowsiness.
A BETTER WAY TO FEEL BETTER: StressCalm is a homeopathic stress relief medicine that has no known interactions with other medications, herbs, or supplements. Its also gluten-free with no artificial sweeteners, flavors, colors, or preservatives.
A TRUSTED BRAND: With more than 90 years of expertise, Boiron medicines are manufactured to meet the highest standards of cGMP and HPUS for purity and quality.

9.0

Excellent

Nature's Bounty

Nature's Bounty Stress Relief Ashwagandha KSM 66 Tablets, Mood Support, 50 Count

Main Highlights

PLANT-BASED STRESS RELIEF: Unlike some other stress supplements Natures Bounty Stress Relief tablets use plant-based ingredients to support a calm state of mind and help you manage occasional stress (1)
SUPPORT FROM ASHWAGANDHA: Natures Bounty Stress Relief tablets contain 600 mg Ashwagandha KSM-66 per serving; Ashwagandha KSM-66 is a clinically studied herbal extract that supports a healthy response to occasional stress (1)
WITH L-THIANINE: Each serving of Natures Bounty Stress Relief contains 200mg of the amino acid L-Theanine to support the mood centers of the brain and promote a calm and relaxed mental state (1)
QUALITY IS OUR PRIORITY: Natures Bounty is committed to the safety of our supplements; Our Stress Relief tablets are non-GMO; gluten free; sugar free; and contain no artificial color; flavor; or sweetener
FROM THE TRUSTED WELLNESS EXPERTS: Natures Bounty Anxiety & Stress Relief tablets are a product of nearly 50 years of dedication to quality; consistency; and scientific research to make vitamins and nutritional supplements of excellence

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Main Highlights

PLANT-BASED STRESS RELIEF: Unlike some other stress supplements Natures Bounty Stress Relief tablets use plant-based ingredients to support a calm state of mind and help you manage occasional stress (1)
SUPPORT FROM ASHWAGANDHA: Natures Bounty Stress Relief tablets contain 600 mg Ashwagandha KSM-66 per serving; Ashwagandha KSM-66 is a clinically studied herbal extract that supports a healthy response to occasional stress (1)
WITH L-THIANINE: Each serving of Natures Bounty Stress Relief contains 200mg of the amino acid L-Theanine to support the mood centers of the brain and promote a calm and relaxed mental state (1)
QUALITY IS OUR PRIORITY: Natures Bounty is committed to the safety of our supplements; Our Stress Relief tablets are non-GMO; gluten free; sugar free; and contain no artificial color; flavor; or sweetener
FROM THE TRUSTED WELLNESS EXPERTS: Natures Bounty Anxiety & Stress Relief tablets are a product of nearly 50 years of dedication to quality; consistency; and scientific research to make vitamins and nutritional supplements of excellence

8.8

Very Good

LifeSeasons

LifeSeasons Anxie-T - Stress Relief Supplement - Supports Mood & Mental Focus - Feel Calm and Relaxed - Eases Tension & Nervousness - Ashwagandha, Kava Kava, GABA & L-Theanine - 60 Capsules

Main Highlights

Health Benefits - Anxie-T supports the bodys natural ability to deal with common symptoms of stress, including nervousness and nervous exhaustion, stress-related muscle tension, anxious fearfulness, and stress-related sleep problems.
Clinically Tested Ingredients - Crafted with all natural ingredients such as Ashwagandha, Kava kava, L-theanine, and Theobromine that all work together. We even use a neurotransmitter called GABA. Its primary role in the body is thought to be the inhibition of nerve excitability.
Effective - Most people experience the relaxing effects of Anxie-T the first day they take it, often within 30 minutes. It usually induces a feeling of calm, and wont make you feel tired.
Day & Night Support - Take two Anxie-T stress support supplements each morning, with or without food. An additional capsule can be added at night to support a good nights sleep.
One Unique Blend - Achieving a change in health requires the right ingredients in the right doses. This used to require purchasing many individual vitamins and nutrients to create an effective blend. LifeSeasons was doctor formulated to put that blend into one bottle.

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Main Highlights

Health Benefits - Anxie-T supports the bodys natural ability to deal with common symptoms of stress, including nervousness and nervous exhaustion, stress-related muscle tension, anxious fearfulness, and stress-related sleep problems.
Clinically Tested Ingredients - Crafted with all natural ingredients such as Ashwagandha, Kava kava, L-theanine, and Theobromine that all work together. We even use a neurotransmitter called GABA. Its primary role in the body is thought to be the inhibition of nerve excitability.
Effective - Most people experience the relaxing effects of Anxie-T the first day they take it, often within 30 minutes. It usually induces a feeling of calm, and wont make you feel tired.
Day & Night Support - Take two Anxie-T stress support supplements each morning, with or without food. An additional capsule can be added at night to support a good nights sleep.
One Unique Blend - Achieving a change in health requires the right ingredients in the right doses. This used to require purchasing many individual vitamins and nutrients to create an effective blend. LifeSeasons was doctor formulated to put that blend into one bottle.

8.6

Very Good

LifeSeasons

Anxie-T Plus - Extra Strength Stress Relief Supplement - Supports Mood & Mental Focus - Feel Calm and Relaxed - Eases Tension & Nervousness - Ashwagandha, Kava Kava, GABA & L-Theanine - 60 Capsules

Main Highlights

Health Benefits - Anxie-T supports the bodys natural ability to deal with common symptoms of stress, including nervousness and nervous exhaustion, stress-related muscle tension, anxious fearfulness, and stress-related sleep problems.
Clinically Tested Ingredients - Crafted with all natural ingredients such as Ashwagandha, Kava kava, L-theanine, and Theobromine that all work together. We even use a neurotransmitter called GABA. Its primary role in the body is thought to be the inhibition of nerve excitability.
Effective - Most people experience the relaxing effects of Anxie-T the first day they take it, often within 30 minutes. It usually induces a feeling of calm, and wont make you feel tired.
Day & Night Support - Take three Anxie-T stress support supplements each morning, with or without food. An additional capsule can be added at night to support a good nights sleep.
One Unique Blend - Achieving a change in health requires the right ingredients in the right doses. This used to require purchasing many individual vitamins and nutrients to create an effective blend. LifeSeasons was doctor formulated to put that blend into one bottle.

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Main Highlights

Health Benefits - Anxie-T supports the bodys natural ability to deal with common symptoms of stress, including nervousness and nervous exhaustion, stress-related muscle tension, anxious fearfulness, and stress-related sleep problems.
Clinically Tested Ingredients - Crafted with all natural ingredients such as Ashwagandha, Kava kava, L-theanine, and Theobromine that all work together. We even use a neurotransmitter called GABA. Its primary role in the body is thought to be the inhibition of nerve excitability.
Effective - Most people experience the relaxing effects of Anxie-T the first day they take it, often within 30 minutes. It usually induces a feeling of calm, and wont make you feel tired.
Day & Night Support - Take three Anxie-T stress support supplements each morning, with or without food. An additional capsule can be added at night to support a good nights sleep.
One Unique Blend - Achieving a change in health requires the right ingredients in the right doses. This used to require purchasing many individual vitamins and nutrients to create an effective blend. LifeSeasons was doctor formulated to put that blend into one bottle.

8.3

Very Good

MARYRUTH'S

MaryRuth Organics Ashwagandha Root | USDA Organic Ashwagandha Liquid Drops | Stress Relief, Natural Calm, Relaxation and Mood Support Supplement | Adaptogenic | Nervine | Vegan | Non-GMO | 60 Servings

Main Highlights

USDA Organic Ashwagandha Root: Let yourself relax and feel great with this long-used herb! Ashwagandha Root (Withania somnifera), has been used in traditional Ayurveda for centuries.
Adaptogenic & Nervine: An important traditional use of this herb is as a nervine one of a group of plants that are traditionally known to have a soothing and supporting effect on the mind and nervous system.
Stress Support: In addition to its traditional use, ashwagandha has been found to be an adaptogen that may help to support calm and relaxation and the bodys natural homeostasis. Let yourself relax and feel great with this long-used herb!
Easy-to-Take Liquid Drops: USDA Organic Ashwagandha Root Liquid Drops can be taken directly by mouth or added to water. Shake well before use. Take up to 15 drops (0.5 mL) 1 to 3 times a day, or as recommended by a physician or healthcare professional.
For Most Lifestyles: MaryRuth's Ashwagandha Root Drops USDA Organic, Non-GMO, Vegan, Made in a GMP Facility. Dairy Free, Nut Free, Gluten Free, Soy Free, Sugar Free, No Synthetic or Artificial Colors, Alcohol Free Tincture. Clean Label Project Certified. B Corp Certified.

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Main Highlights

USDA Organic Ashwagandha Root: Let yourself relax and feel great with this long-used herb! Ashwagandha Root (Withania somnifera), has been used in traditional Ayurveda for centuries.
Adaptogenic & Nervine: An important traditional use of this herb is as a nervine one of a group of plants that are traditionally known to have a soothing and supporting effect on the mind and nervous system.
Stress Support: In addition to its traditional use, ashwagandha has been found to be an adaptogen that may help to support calm and relaxation and the bodys natural homeostasis. Let yourself relax and feel great with this long-used herb!
Easy-to-Take Liquid Drops: USDA Organic Ashwagandha Root Liquid Drops can be taken directly by mouth or added to water. Shake well before use. Take up to 15 drops (0.5 mL) 1 to 3 times a day, or as recommended by a physician or healthcare professional.
For Most Lifestyles: MaryRuth's Ashwagandha Root Drops USDA Organic, Non-GMO, Vegan, Made in a GMP Facility. Dairy Free, Nut Free, Gluten Free, Soy Free, Sugar Free, No Synthetic or Artificial Colors, Alcohol Free Tincture. Clean Label Project Certified. B Corp Certified.

8.1

Very Good

Source Naturals

Source Naturals St. John's Positive Thoughts, Supports A Good Mood* - 90 Tablets

Main Highlights

SOURCE NATURALS BENEFITS. St. John's Positive Thoughts combines mood-soothing herbs, calming factors, and uplifting amino acids.
SUGGESTED USE. 3 tablets daily. For optimal absorption, take between meals or with a carbohydrate meal. One tablet can be taken before bedtime. For best results, use this product for at least 6 weeks, although benefits may be experienced sooner.
WELL MADE SUPPLE MENT. It contains the standardized herbal extract of St. John's wort yielding 0.3% hypericins. It also features valerian, Relora, GABA, magnesium, and the amino acids taurine, N-acetyl L-tyrosine, L-theanine, and L-phenylalanine.
TRUSTED FOR OVER 35 YEARS. Source Naturals was created in 1982 by CEO Ira Goldberg to support each individual's potential to enjoy optimal health.
MANUFACTURED IN THE USA. Our facility is located in Scotts Valley California.

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Main Highlights

SOURCE NATURALS BENEFITS. St. John's Positive Thoughts combines mood-soothing herbs, calming factors, and uplifting amino acids.
SUGGESTED USE. 3 tablets daily. For optimal absorption, take between meals or with a carbohydrate meal. One tablet can be taken before bedtime. For best results, use this product for at least 6 weeks, although benefits may be experienced sooner.
WELL MADE SUPPLE MENT. It contains the standardized herbal extract of St. John's wort yielding 0.3% hypericins. It also features valerian, Relora, GABA, magnesium, and the amino acids taurine, N-acetyl L-tyrosine, L-theanine, and L-phenylalanine.
TRUSTED FOR OVER 35 YEARS. Source Naturals was created in 1982 by CEO Ira Goldberg to support each individual's potential to enjoy optimal health.
MANUFACTURED IN THE USA. Our facility is located in Scotts Valley California.

8.1

Very Good

OLLY

OLLY Ultra Strength Goodbye Stress Softgels, GABA, Ashwagandha, L-Theanine and Lemon Balm, Stress Relief Supplement - 60 Count

Main Highlights

OLLY ULTRA STRENGTH GOODBYE STRESS ULTRA SOFTGEL: Goodbye Stress Ultra Softgels are blended with powerful botanicals and nutrients to help you stay calm and centered
THE GOODS INSIDE: OLLY Goodbye Stress softgels are expertly blended with GABA, a fast working (within 30-60 minutes) active that supports a relaxed state of mind. L-Theanine is GABA's partner in sublimeit goes right to work in your brain to help you keep your cool, and Lemon Balm is a soothing botanical that has been used for centuries to help quiet the mind. Plus Ashwagandha for mood and energy support
HOW TO TAKE: Take 2 softgels per day with water as needed. Swallow whole, do not chew. Comes with 60 capsules per bottle for a 30 day supply
ULTRA SOFTGELS: Our premium Softgel blends are naturally colored, easy to swallow and have a hint of strawberry scent with zero sugar. This stress aid supplement also come in a convenient compact package.
MIX AND MATCH: Delightful OLLY products can be taken togethermix and match as you please
MORE OLLY GOODNESS: We create products that are just as effective as they are deliciousgummies, multivitamins, drink powders, premium softgels and more ways to feel happy inside out

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Main Highlights

OLLY ULTRA STRENGTH GOODBYE STRESS ULTRA SOFTGEL: Goodbye Stress Ultra Softgels are blended with powerful botanicals and nutrients to help you stay calm and centered
THE GOODS INSIDE: OLLY Goodbye Stress softgels are expertly blended with GABA, a fast working (within 30-60 minutes) active that supports a relaxed state of mind. L-Theanine is GABA's partner in sublimeit goes right to work in your brain to help you keep your cool, and Lemon Balm is a soothing botanical that has been used for centuries to help quiet the mind. Plus Ashwagandha for mood and energy support
HOW TO TAKE: Take 2 softgels per day with water as needed. Swallow whole, do not chew. Comes with 60 capsules per bottle for a 30 day supply
ULTRA SOFTGELS: Our premium Softgel blends are naturally colored, easy to swallow and have a hint of strawberry scent with zero sugar. This stress aid supplement also come in a convenient compact package.
MIX AND MATCH: Delightful OLLY products can be taken togethermix and match as you please
MORE OLLY GOODNESS: We create products that are just as effective as they are deliciousgummies, multivitamins, drink powders, premium softgels and more ways to feel happy inside out

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